Background:

The protein encoded by UMOD (uromodulin) is the most abundant protein in mammalian urine under physiological conditions. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. This protein may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of this protein in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in UMOD are associated with the renal disorders medullary cystic kidney disease-2 (MCKD2), glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI), and familial juvenile hyperuricemic nephropathy (FJHN). Alternative splicing of UMOD results in multiple transcript variants.

Classification:

Primary antibody

Alternative names:

UMOD; Uromodulin; Tamm-Horsfall urinary glycoprotein; THP

Species reactivity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human THP. AA range:329-378

Concentration:

1 mg/ml

Molecular weight:

69761

Applications:

WB, ELISA

Storage:

-20°C for one year

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