Background:

TNXB (tenascin XB) encodes a member of the tenascin family of extracellular matrix glycoproteins. The tenascins have anti-adhesive effects, as opposed to fibronectin which is adhesive. This protein is thought to function in matrix maturation during wound healing, and its deficiency has been associated with the connective tissue disorder Ehlers-Danlos syndrome. TNXB localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. It is one of four genes in this cluster which have been duplicated. The duplicated copy of this gene is incomplete and is a pseudogene which is transcribed but does not encode a protein. The structure of TNXB is unusual in that it overlaps the CREBL1 and CYP21A2 genes at its 5' and 3' ends, respectively. Multiple transcript variants encoding different isoforms have been found for TNXB.

Classification:

Primary antibody

Alternative names:

TNXB; HXBL; TNX; TNXB1; TNXB2; XB; Tenascin-X; TN-X; Hexabrachion-like protein

Species reactivity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human TNXB. AA range:1761-1810

Concentration:

1 mg/ml

Molecular weight:

464456

Applications:

IHC-p, ELISA

Storage:

-20°C for one year

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