Background:

The chaperonin containing TCP1 subunit 5 encoded by CCT5 is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Mutations in this gene cause hereditary sensory and autonomic neuropathy with spastic paraplegia (HSNSP). Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 13.

Classification:

Primary antibody

Alternative names:

CCT5; CCTE; KIAA0098; T-complex protein 1 subunit epsilon; TCP-1-epsilon; CCT-epsilon

Species reactivity:

Human;Mouse;Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human CCT5. AA range:241-290

Concentration:

1 mg/ml

Molecular weight:

59671

Applications:

WB, ELISA

Storage:

-20°C for one year

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