Background:

ST5 was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. Suppression of tumorigenicity 5 protein encoded by ST5 contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified.

Classification:

Primary antibody

Alternative names:

ST5; DENND2B; HTS1; Suppression of tumorigenicity 5 protein; DENN domain-containing protein 2B; HeLa tumor suppression 1

Species reactivity:

Human;Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human ST5. AA range:411-460

Concentration:

1 mg/ml

Molecular weight:

126499

Applications:

WB, ELISA

Storage:

-20°C for one year

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