Background:

SPTLC1 encodes a member of the class-II pyridoxal-phosphate-dependent aminotransferase family. The serine palmitoyltransferase long chain base subunit 1 is the long chain base subunit 1 of serine palmitoyltransferase. Serine palmitoyltransferase converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate and is the key enzyme in sphingolipid biosynthesis. Mutations in this gene were identified in patients with hereditary sensory neuropathy type 1. Alternatively spliced variants encoding different isoforms have been identified. Pseudogenes of this gene have been defined on chromosomes 1, 6, 10, and 13.

Classification:

Primary antibody

Alternative names:

SPTLC1; LCB1; Serine palmitoyltransferase 1; Long chain base biosynthesis protein 1; LCB 1; Serine-palmitoyl-CoA transferase 1; SPT 1; SPT1

Species reactivity:

Human;Mouse;Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from SPTLC1 . at AA range: 411-460

Concentration:

1 mg/ml

Molecular weight:

52030

Applications:

WB, IHC-p, ELISA

Storage:

-20°C for one year

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