Background:

SPARC encodes a cysteine-rich acidic matrix-associated protein. The secreted protein acidic and cysteine rich is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. Three transcript variants encoding different isoforms have been found for this gene.

Classification:

Primary antibody

Alternative names:

SPARC; ON; SPARC; Basement-membrane protein 40; BM-40; Osteonectin; ON; Secreted protein acidic and rich in cysteine

Species reactivity:

Human;Mouse;Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from the Internal region of human SPARC. AA range:141-190

Concentration:

1 mg/ml

Molecular weight:

33330

Applications:

WB, IHC-p, ELISA

Storage:

-20°C for one year

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