Background:

Ski-like protein encoded by SKIL is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene.

Classification:

Primary antibody

Alternative names:

SKIL; SNO; Ski-like protein; Ski-related oncogene; Ski-related protein

Species reactivity:

Human;Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human SKIL. AA range:616-665

Concentration:

1 mg/ml

Molecular weight:

77004

Applications:

WB, IHC-p, ELISA

Storage:

-20°C for one year

More info:

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