Background:

MBTPS2 (membrane bound transcription factor peptidase, site 2) encodes a intramembrane zinc metalloprotease, which is essential in development. This protease functions in the signal protein activation involved in sterol control of transcription and the ER stress response. Mutations in MBTPS2 have been associated with ichthyosis follicularis with atrichia and photophobia (IFAP syndrome); IFAP syndrome has been quantitatively linked to a reduction in cholesterol homeostasis and ER stress response.

Classification:

Primary antibody

Alternative names:

MBTPS2; S2P; Membrane-bound transcription factor site-2 protease; Endopeptidase S2P; Sterol regulatory element-binding proteins intramembrane protease; SREBPs intramembrane protease

Species reactivity:

Human;Mouse;Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human MBTPS2. AA range:301-350

Concentration:

1 mg/ml

Molecular weight:

57444

Applications:

IF, ELISA

Storage:

-20°C for one year

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