Background:

RTKN (rhotekin) encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.

Classification:

Primary antibody

Alternative names:

RTKN; RTKN1; Rhotekin

Species reactivity:

Human;Mouse;Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from Rhotekin . at AA range: 80-160

Concentration:

1 mg/ml

Molecular weight:

62667

Applications:

IHC-p, ELISA

Storage:

-20°C for one year

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