Background:

RGS14 encodes a member of the regulator of G-protein signaling family. Regulator of G-protein signaling 14 contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Classification:

Primary antibody

Alternative names:

RGS14; Regulator of G-protein signaling 14; RGS14

Species reactivity:

Human;Mouse;Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human RGS14. AA range:125-174

Concentration:

1 mg/ml

Molecular weight:

64922

Applications:

WB, ELISA

Storage:

-20°C for one year

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