Background:

CDH4 is a classical cadherin from the cadherin superfamily. The cadherin 4 is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene.

Classification:

Primary antibody

Alternative names:

CDH4; Cadherin-4; Retinal cadherin; R-CAD; R-cadherin

Species reactivity:

Human;Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human CDH4. AA range:731-780

Concentration:

1 mg/ml

Molecular weight:

100281

Applications:

IHC-p, IF, ELISA

Storage:

-20°C for one year

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