Background:

Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis.

Classification:

Primary antibody

Alternative names:

RAB3IP; RABIN8; Rab-3A-interacting protein; Rab3A-interacting protein; Rabin-3; SSX2-interacting protein

Species reactivity:

Human;Mouse;Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human RAB3IP. AA range:257-306

Concentration:

1 mg/ml

Molecular weight:

53021

Applications:

WB, IHC-p, ELISA

Storage:

-20°C for one year

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