Background:

PTPN22 encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The protein tyrosine phosphatase, non-receptor type 22 is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Classification:

Primary antibody

Alternative names:

PTPN22; PTPN8; Tyrosine-protein phosphatase non-receptor type 22; Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP; Lymphoid phosphatase; LyP; PEST-domain phosphatase; PEP

Species reactivity:

Human;Mouse;Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from the N-terminal region of human PTP22.

Concentration:

1 mg/ml

Molecular weight:

91705

Applications:

WB, ELISA

Storage:

-20°C for one year

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