Background:

The protein encoded by MAPKAPK5 (mitogen-activated protein kinase-activated protein kinase 5) is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of MAPKAPK5 encoding distinct isoforms have been reported.

Classification:

Primary antibody

Alternative names:

MAPKAPK5; PRAK; MAP kinase-activated protein kinase 5; MAPK-activated protein kinase 5; MAPKAP kinase 5; MAPKAP-K5; MAPKAPK-5; MK-5; MK5; p38-regulated/activated protein kinase; PRAK

Species reactivity:

Human;Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human MAPKAPK5. AA range:171-220

Concentration:

1 mg/ml

Molecular weight:

54220

Applications:

IHC-p, ELISA

Storage:

-20°C for one year

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