Background:

Tumor protein p53 inducible protein 3 encoded by TP53I3 is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. TP53I3 is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate TP53I3 by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. Alternatively spliced transcript variants encoding different isoforms have been found for TP53I3.

Classification:

Primary antibody

Alternative names:

TP53I3; PIG3; Quinone oxidoreductase PIG3; Tumor protein p53-inducible protein 3; p53-induced gene 3 protein

Species reactivity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human QORX. AA range:241-290

Concentration:

1 mg/ml

Molecular weight:

35536

Applications:

WB, IHC-p, ELISA

Storage:

-20°C for one year

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