Background:

PTGIS (prostaglandin I2 (prostacyclin) synthase) encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis.

Classification:

Primary antibody

Alternative names:

PTGIS; CYP8; CYP8A1; Prostacyclin synthase; Prostaglandin I2 synthase

Species reactivity:

Human;Mouse;Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from the C-terminal region of human PGI2 synthase.

Concentration:

1 mg/ml

Molecular weight:

57104

Applications:

WB, ELISA

Storage:

-20°C for one year

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