Background:

The protein encoded by PRF1 (perforin 1) has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in PRF1 cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein.

Classification:

Primary antibody

Alternative names:

Perforin-1 (P1) (Cytolysin) (Lymphocyte pore-forming protein) (PFP)

Species reactivity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from the C-terminal region of human PRF1. AA range:451-500

Concentration:

1 mg/ml

Molecular weight:

61377

Applications:

WB, IHC, ELISA

Storage:

-20°C for one year

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