Background:

PER3 (period circadian clock 3) is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. PER3 is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in PER3 have been linked to sleep disorders. Multiple transcript variants encoding different isoforms have been found for PER3.

Classification:

Primary antibody

Alternative names:

PER3; GIG13; Period circadian protein homolog 3; hPER3; Cell growth-inhibiting gene 13 protein; Circadian clock protein PERIOD 3

Species reactivity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human PER3. AA range:21-70

Concentration:

1 mg/ml

Molecular weight:

131872/43102

Applications:

WB, IHC-p, ELISA

Storage:

-20°C for one year

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