Background:

PGA5 (pepsinogen 5, group I (pepsinogen A)) encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. PGA5 is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric cancer.

Classification:

Primary antibody

Alternative names:

Pepsin A; PGA3; PGA4; PGA5

Species reactivity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human Pepsin A. AA range:258-307

Concentration:

1 mg/ml

Molecular weight:

41977

Applications:

WB, IHC-p, ELISA

Storage:

-20°C for one year

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