Background:

PC encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene.

Classification:

Primary antibody

Alternative names:

PC; Pyruvate carboxylase; mitochondrial; Pyruvic carboxylase; PCB

Species reactivity:

Human;Mouse;Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human PC. AA range:357-406

Concentration:

1 mg/ml

Molecular weight:

129634

Applications:

WB, IHC-p, ELISA

Storage:

-20°C for one year

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