Background:

SESN1 encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The sestrin 1 mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Classification:

Primary antibody

Alternative names:

SESN1; PA26; SEST1; Sestrin-1; p53-regulated protein PA26

Species reactivity:

Human;Mouse;Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human SESN1. AA range:271-320

Concentration:

1 mg/ml

Molecular weight:

56557

Applications:

WB, IHC-p, ELISA

Storage:

-20°C for one year

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