Background:

TP53 encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains.Tumor protein p53 responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in TP53 are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of TP53 and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277).

Classification:

Primary antibody

Alternative names:

TP53; P53; Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53

Species reactivity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized acetyl-peptide derived from the human p53 around the acetylation site of K382.

Concentration:

1 mg/ml

Molecular weight:

43653

Applications:

WB, IHC-p, ELISA

Storage:

-20°C for one year

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