Background:

EP300 encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. EP300 has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in EP300 are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.

Classification:

Primary antibody

Alternative names:

EP300; P300; Histone acetyltransferase p300; p300 HAT; E1A-associated protein p300

Species reactivity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human p300. AA range:1-50

Concentration:

1 mg/ml

Molecular weight:

264144

Applications:

WB, IHC-p, ELISA

Storage:

-20°C for one year

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