Background:

The cyclin dependent kinase inhibitor 2D encoded by CDKN2D is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported.

Classification:

Primary antibody

Alternative names:

CDKN2D; Cyclin-dependent kinase 4 inhibitor D; p19-INK4d

Species reactivity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human CDKN2D. AA range:96-145

Concentration:

1 mg/ml

Molecular weight:

17700

Applications:

IHC-p, ELISA

Storage:

-20°C for one year

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