Background:

Cyclin dependent kinase inhibitor 2C encoded by CDKN2C is a member of the INK4 family of cyclin-dependent kinase inhibitors. Cyclin dependent kinase inhibitor 2C has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of CDKN2C was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of CDKN2C in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of CDKN2C, which encode an identical protein, have been reported.

Classification:

Primary antibody

Alternative names:

CDKN2C; CDKN6; Cyclin-dependent kinase 4 inhibitor C; Cyclin-dependent kinase 6 inhibitor; p18-INK4c; p18-INK6

Species reactivity:

Human;Mouse;Monkey

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human p18 INK. AA range:111-160

Concentration:

1 mg/ml

Molecular weight:

18127

Applications:

WB, IHC-p, ELISA

Storage:

-20°C for one year

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