Background:

NXF3 (nuclear RNA export factor 3) is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of NXF3 has shortened LRR and ubiquitin-associated domains and its RDB is unable to bind RNA. It is located in the nucleoplasm but is not associated with either the nuclear envelope or the nucleolus.

Classification:

Primary antibody

Alternative names:

NXF3; TAPL3; Nuclear RNA export factor 3; TAP-like protein 3; TAPL-3

Species reactivity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human NXF3. AA range:72-121

Concentration:

1 mg/ml

Molecular weight:

60102

Applications:

WB, IHC-p, ELISA

Storage:

-20°C for one year

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