Background:

The nuclear pore complex (NPC) mediates bidirectional macromolecular traffic between the nucleus and cytoplasm in eukaryotic cells and is comprised of more than 100 different subunits. Many of the subunits belong to a family called nucleoporins (Nups), which are characterized by the presence of O-linked-N-acetylglucosamine moieties and a distinctive pentapeptide repeat (XFXFG). Nup93 (nucleoporin 93) is the most abundant nucleoporin found per NPC, contributing over 10% of the mass. It localizes to the nuclear side of the NPC, predominantly in the basket terminal ring area, and exists in a complex with Nup188, Nup53 and Nup205. This complex is crucial for NPC stability and proper assembly. Nup93 interacts directly with the Nup62 complex located at the center of the NPC and thus tethers the two subcomplexes. Nup93 is composed of a coiled-coil domain at its N-terminus and a C-terminal helical domain. Its proper function is essential for cell viability and normal NPC function.

Classification:

Primary antibody

Alternative names:

NUP93; KIAA0095; Nuclear pore complex protein Nup93; 93 kDa nucleoporin; Nucleoporin Nup93

Species reactivity:

Human;Mouse;Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human NUP93. AA range:221-270

Concentration:

1 mg/ml

Molecular weight:

93488

Applications:

WB, ELISA

Storage:

-20°C for one year

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