Background:

PNPLA6 encodes a phospholipase that deacetylates intracellular phosphatidylcholine to produce glycerophosphocholine. It is thought to function in neurite outgrowth and process elongation during neuronal differentiation. The patatin like phospholipase domain containing 6 is anchored to the cytoplasmic face of the endoplasmic reticulum in both neurons and non-neuronal cells. Mutations in this gene result in autosomal recessive spastic paraplegia, and the protein is the target for neurodegeneration induced by organophosphorus compounds and chemical warfare agents. Multiple transcript variants encoding different isoforms have been found for this gene.

Classification:

Primary antibody

Alternative names:

PNPLA6; NTE; Neuropathy target esterase; Patatin-like phospholipase domain-containing protein 6

Species reactivity:

Human;Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human PNPLA6. AA range:102-151

Concentration:

1 mg/ml

Molecular weight:

149995

Applications:

WB, ELISA

Storage:

-20°C for one year

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