Background:

The erythroid-specific protein encoded by NFE4, and the ubiquitous transcription factor CP2, form the stage selector protein(SSP) complex, which is involved in preferential expression of the gamma-globin genes in fetal erythroid cells. Alternate use of an in-frame upstream non-AUG(CUG) translation initiation codon, and a downstream AUG codon, results in two isoforms. While the long isoform(22 kDa) acts as an activator, the short isoform(14 kDa) has been shown to repress gamma-globin gene expression. NFE4 is located in an intron of the FBXL13 gene on the opposite strand.

Classification:

Primary antibody

Alternative names:

NFE4; Transcription factor NF-E4

Species reactivity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized acetyl-peptide derived from the human NF-E4 around the acetylation site of K43.

Concentration:

1 mg/ml

Molecular weight:

19019

Applications:

WB, ELISA

Storage:

-20°C for one year

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