Background:

NPHS1 encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. NPHS1 is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.

Classification:

Primary antibody

Alternative names:

NPHS1; NPHN; Nephrin; Renal glomerulus-specific cell adhesion receptor

Species reactivity:

Human;Mouse;Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human Nephrin. AA range:843-892

Concentration:

1 mg/ml

Molecular weight:

134742

Applications:

IHC-p, ELISA

Storage:

-20°C for one year

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