Background:

NEDD8 is a Protein Coding gene. Among its related pathways are Signaling by GPCR and p53 pathway (Pathway Interaction Database). Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is UBA52.

Classification:

Primary antibody

Alternative names:

NEDD8; NEDD8; Neddylin; Neural precursor cell expressed developmentally down-regulated protein 8; NEDD-8; Ubiquitin-like protein Nedd8

Species reactivity:

Human;Mouse;Rat;Monkey

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human NEDD8. AA range:10-59

Concentration:

1 mg/ml

Molecular weight:

9072

Applications:

WB, IHC-p, ELISA

Storage:

-20°C for one year

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