Background:

The protein encoded by L1CAM is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of L1CAM results in multiple transcript variants, some of which include an alternate exon that is considered to be specific to neurons.

Classification:

Primary antibody

Alternative names:

Neural cell adhesion molecule L1 (N-CAM-L1) (NCAM-L1) (CD antigen CD171)

Species reactivity:

Human;Mouse;Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthetic peptide from human protein at AA range: 151-200

Concentration:

1 mg/ml

Molecular weight:

140003

Applications:

IHC-p, ELISA

Storage:

-20°C for one year

More info:

Email: info@sobekbio.com

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