Background:

MYO5A is one of three myosin V heavy-chain genes, belonging to the myosin gene superfamily. Myosin V is a class of actin-based motor proteins involved in cytoplasmic vesicle transport and anchorage, spindle-pole alignment and mRNA translocation. The protein encoded by MYO5A is abundant in melanocytes and nerve cells. Mutations in this gene cause Griscelli syndrome type-1 (GS1), Griscelli syndrome type-3 (GS3) and neuroectodermal melanolysosomal disease, or Elejalde disease. Multiple alternatively spliced transcript variants encoding different isoforms have been reported, but the full-length nature of some variants has not been determined.

Classification:

Primary antibody

Alternative names:

MYO5A; MYH12; Unconventional myosin-Va; Dilute myosin heavy chain; non-muscle; Myosin heavy chain 12; Myosin-12; Myoxin

Species reactivity:

Human;Mouse;Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human MYO5A. AA range:1784-1833

Concentration:

1 mg/ml

Molecular weight:

215421

Applications:

WB, ELISA

Storage:

-20°C for one year

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