Background:

The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. MNT encodes a protein member of the Myc/Max/Mad network. Max-binding protein MNT has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. Max-binding protein MNT is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. Max-binding protein MNT represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain.

Classification:

Primary antibody

Alternative names:

MNT; BHLHD3; ROX; Max-binding protein MNT; Class D basic helix-loop-helix protein 3; bHLHd3; Myc antagonist MNT; Protein ROX

Species reactivity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human MNT. AA range:315-364

Concentration:

1 mg/ml

Molecular weight:

62300

Applications:

WB, ELISA

Storage:

-20°C for one year

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