Background:

MLTK is a member of the MAPKKK family of signal transduction molecules and encodes a protein, Mitogen-activated protein kinase kinase kinase MLT, with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Classification:

Primary antibody

Alternative names:

MLTK; ZAK; HCCS4; Mitogen-activated protein kinase kinase kinase MLT; Human cervical cancer suppressor gene 4 protein; HCCS-4; Leucine zipper- and sterile alpha motif-containing kinase; MLK-like mitog

Species reactivity:

Human;Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human MLTK. AA range:701-750

Concentration:

1 mg/ml

Molecular weight:

91181

Applications:

WB, IF, ELISA

Storage:

-20°C for one year

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