Background:

MLKL belongs to the protein kinase superfamily. Mixed lineage kinase domain-like protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. Mixed lineage kinase domain-like protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.

Classification:

Primary antibody

Alternative names:

MLKL; Mixed lineage kinase domain-like protein

Species reactivity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from MLKL . at AA range: 40-120

Concentration:

1 mg/ml

Molecular weight:

54479

Applications:

WB, ELISA

Storage:

-20°C for one year

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