Background:

MLH3 is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The mutL homolog 3 encoded by MLH3 functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.

Classification:

Primary antibody

Alternative names:

MLH3; DNA mismatch repair protein Mlh3; MutL protein homolog 3

Species reactivity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human MLH3. AA range:521-570

Concentration:

1 mg/ml

Molecular weight:

163712

Applications:

WB, IHC-p, ELISA

Storage:

-20°C for one year

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