Background:

SLC16A2 (solute carrier family 16 member 2) encodes an integral membrane protein that functions as a transporter of thyroid hormone. The encoded protein facilitates the cellular importation of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). SLC16A2 is expressed in many tissues and likely plays an important role in the development of the central nervous system. Loss of function mutations in SLC16A2 are associated with psychomotor retardation in males while females exhibit no neurological defects and more moderate thyroid-deficient phenotypes. SLC16A2 is subject to X-chromosome inactivation. Mutations in SLC16A2 are the cause of Allan-Herndon-Dudley syndrome.

Classification:

Primary antibody

Alternative names:

SLC16A2; MCT8; XPCT; Monocarboxylate transporter 8; MCT 8; Monocarboxylate transporter 7; MCT 7; Solute carrier family 16 member 2; X-linked PEST-containing transporter

Species reactivity:

Human;Mouse;Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human SLC16A2. AA range:112-161

Concentration:

1 mg/ml

Molecular weight:

59511

Applications:

WB, ELISA

Storage:

-20°C for one year

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