Background:

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. MBD3 belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD). Methyl-CpG-binding domain protein 3 is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. Unlike the other family members, the encoded protein is not capable of binding to methylated DNA. The protein mediates the association of metastasis-associated protein 2 with the core histone deacetylase complex. Alternative splicing results in multiple transcript variants of this gene.

Classification:

Primary antibody

Alternative names:

MBD3; Methyl-CpG-binding domain protein 3; Methyl-CpG-binding protein MBD3

Species reactivity:

Human;Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human MBD3. AA range:221-270

Concentration:

1 mg/ml

Molecular weight:

32844

Applications:

WB, ELISA

Storage:

-20°C for one year

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