Background:

LIFR encodes leukemia inhibitory factor receptor alpha that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding the same protein have been found for this gene.

Classification:

Primary antibody

Alternative names:

LIFR; Leukemia inhibitory factor receptor; LIF receptor; LIF-R; CD118

Species reactivity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from the Internal region of human LIFR. AA range:731-780

Concentration:

1 mg/ml

Molecular weight:

123743

Applications:

WB, ELISA

Storage:

-20°C for one year

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