Background:

Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential.

Classification:

Primary antibody

Alternative names:

JTB; HSPC222; Protein JTB; Jumping translocation breakpoint protein; Prostate androgen-regulated protein; PAR protein

Species reactivity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human JTB. AA range:10-59

Concentration:

1 mg/ml

Molecular weight:

16358

Applications:

WB, ELISA

Storage:

-20°C for one year

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