Background:

The chondroitin sulfate proteoglycan NG2 is a type I membrane protein expressed by subpopulations of glia including oligodendroglial precursor cells and a variety of tumor cells. Normal precursor cells and malignant tumor cells migrate and proliferate, but there is evidence that cells may not be able to engage in both activities at the same time. However, NG2 is involved in promoting both proliferation and motility. The extracellular domain of NG2 sequesters growth factors and binds to both growth factor receptors and extracellular matrix ligands such as fibronectin, collagens and laminin. The cytoplasmic domain is involved in activating Rac, Cdc42 and p130 Cas. PKCα phosphorylates NG2 at Thr2256, triggering the redistribution of NG2 from apical microprocesses to lamellipodia accompanied by enhanced cell motility. ERK phosphorylates NG2 at Thr2314, stimulating cell proliferation.

Classification:

Primary antibody

Alternative names:

NSG2; Neuron-specific protein family member 2; Protein p19; Hmp19

Species reactivity:

Human;Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human NSG2. AA range:33-82

Concentration:

1 mg/ml

Molecular weight:

19085

Applications:

IHC-p, WB, ELISA

Storage:

-20°C for one year

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