Background:

HR encodes a protein that is involved in hair growth. Protein hairless functions as a transcriptional corepressor of multiple nuclear receptors, including thyroid hormone receptor, the retinoic acid receptor-related orphan receptors and the vitamin D receptors, and it interacts with histone deacetylases. The translation of Protein hairless is modulated by a regulatory open reading frame (ORF) that exists upstream of the primary ORF. Mutations in this upstream ORF cause Marie Unna hereditary hypotrichosis (MUHH), an autosomal dominant form of genetic hair loss. Mutations in this gene also cause autosomal recessive congenital alopecia and atrichia with papular lesions, other diseases resulting in hair loss. Two transcript variants encoding different isoforms have been found for this gene.

Classification:

Primary antibody

Alternative names:

HR; Protein hairless

Species reactivity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human HAIR. AA range:41-90

Concentration:

1 mg/ml

Molecular weight:

127495

Applications:

WB, IHC-p, IF, ELISA

Storage:

-20°C for one year

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