Background:

GPS2 encodes G protein pathway suppressor 2 involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function.

Classification:

Primary antibody

Alternative names:

GPS2; G protein pathway suppressor 2; GPS-2

Species reactivity:

Human;Mouse;Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human GPS2. AA range:11-60

Concentration:

1 mg/ml

Molecular weight:

36689

Applications:

WB, ELISA

Storage:

-20°C for one year

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