Background:

MSTN encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and other mammals.

Classification:

Primary antibody

Alternative names:

MSTN; GDF8; Growth/differentiation factor 8; GDF-8; Myostatin

Species reactivity:

Human;Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human GDF-8. AA range:38-87

Concentration:

1 mg/ml

Molecular weight:

42750

Applications:

IHC-p, ELISA

Storage:

-20°C for one year

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