Background:

Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. The GABA-A receptor is generally pentameric and there are five types of subunits: alpha, beta, gamma, delta, and rho. GABRD encodes the delta subunit. Mutations in this gene have been associated with susceptibility to generalized epilepsy with febrile seizures, type 5. Alternatively spliced transcript variants have been described for this gene, but their biological validity has not been determined.

Classification:

Primary antibody

Alternative names:

GABRD; Gamma-aminobutyric acid receptor subunit delta; GABA(A) receptor subunit delta

Species reactivity:

Human;Mouse;Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human GABRD. AA range:141-190

Concentration:

1 mg/ml

Molecular weight:

50708

Applications:

WB, IHC-p, ELISA

Storage:

-20°C for one year

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