Background:

GABRA1 encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple transcript variants encoding the same protein have been identified for this gene.

Classification:

Primary antibody

Alternative names:

GABRA1; Gamma-aminobutyric acid receptor subunit alpha-1; GABA(A) receptor subunit alpha-1

Species reactivity:

Human;Mouse;Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human GABAA Ralpha1. AA range:312-361

Concentration:

1 mg/ml

Molecular weight:

51802

Applications:

IHC-p, WB, ELISA

Storage:

-20°C for one year

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