Background:

ZC3H8 is a Protein Coding gene. Zinc finger CCCH domain-containing protein 8 acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5-AGGTCTC-3 sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:23932780). Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis. Among its related pathways are Gene Expression and RNA Polymerase II Transcription Initiation And Promoter Clearance. GO annotations related to this gene include poly (A) RNA binding and sequence-specific DNA binding. An important paralog of this gene is ZC3H4.

Classification:

Primary antibody

Alternative names:

ZC3H8; ZC3HDC8; Zinc finger CCCH domain-containing protein 8

Species reactivity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human ZC3H8. AA range:81-130

Concentration:

1 mg/ml

Molecular weight:

33576

Applications:

WB, IHC-p, ELISA

Storage:

-20°C for one year

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