Background:

FARP2 is a Protein Coding gene. FERM RhoGEF and pleckstrin domain-containing protein 2 functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion. Diseases associated with FARP2 include verheij syndrome and aarskog-scott syndrome. Among its related pathways are Developmental Biology and Adherens junction. GO annotations related to this gene include Rho guanyl-nucleotide exchange factor activity and Rac guanyl-nucleotide exchange factor activity. An important paralog of this gene is FRMD3.

Classification:

Primary antibody

Alternative names:

FARP2; KIAA0793; PLEKHC3; FERM; RhoGEF and pleckstrin domain-containing protein 2; FERM domain including RhoGEF; FIR; Pleckstrin homology domain-containing family C member 3; PH domain-containing fam

Species reactivity:

Human;Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human FIR. AA range:331-380

Concentration:

1 mg/ml

Molecular weight:

119888

Applications:

WB, IF, ELISA

Storage:

-20°C for one year

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