Background:

Filamin-A encoded by FLNA is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. Filamin-A is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. Filamin-A interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in FLNA are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.

Classification:

Primary antibody

Alternative names:

FLNA; FLN; FLN1; Filamin-A; FLN-A; Actin-binding protein 280; ABP-280; Alpha-filamin; Endothelial actin-binding protein; Filamin-1; Non-muscle filamin

Species reactivity:

Human;Mouse;Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human Filamin A. AA range:2121-2170

Concentration:

1 mg/ml

Molecular weight:

280608

Applications:

WB, IHC-p, ELISA

Storage:

-20°C for one year

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